KPV in published cell and mouse studies

What papers reported

Work on the tripeptide KPV (Lys-Pro-Val) cited here is experimental. Findings are study reports, not statements about use in people or animals.

In vitro. Dalmasso and colleagues (2008) reported that KPV was taken up in cells expressing the peptide transporter PepT1. In stimulated intestinal epithelial and immune-cell cultures, they reported lower NF-κB transcriptional activity and lower IL-8 release than in stimulated comparison conditions. Limitation: these are cell systems; they do not show what occurs in an intact organism.

Animal model. The same paper reported that, in dextran sulfate sodium and CD4+ CD45RB-high T-cell transfer mouse models of colitis, animals given KPV had lower histologic inflammation scores and lower measured proinflammatory cytokines than model comparison groups. Kannengiesser and colleagues (2008) reported, in murine models of inflammatory bowel disease, lower histologic inflammatory-cell infiltration and lower myeloperoxidase activity relative to model controls. Limitation: both sets of results are from mice. This briefing does not summarize a clinical trial.

Sources

• PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation. 2008. https://pubmed.ncbi.nlm.nih.gov/18166354/
• Melanocortin-derived tripeptide KPV has anti-inflammatory potential in murine models of inflammatory bowel disease. 2008. https://pubmed.ncbi.nlm.nih.gov/18092346/